TBI-p-2010-4
Download:
Titel:
RNALfoldz: efficient prediction of thermodynamically stable, local secondary structures
Author(s):
Andreas R. Gruber, Stephan H. Bernhart, You Zhou, and Ivo L. Hofacker
submitted to:
Abstract:
The search for local RNA secondary structures and the
annotation of unusually stable folding regions in genomic sequences
are two well motivated bioinformatic problems. In this contribution
we introduce RNALfoldz an efficient solution two tackle both tasks.
It is an extension of the RNALfold algorithm augmented by support
vector regression for efficient calculation of a structure's thermody-
namic stability. We demonstrate the applicability of this approach
on the genome of E. coli and investigate a potential strategy to
determine z-score cutoffs given a predefined false discovery rate.
Link to publication:
Return to Index
Return to List
Last modified: 2008-10-22 12:23:11 fall