TBI-p-2014-10

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Titel:
Comparative Detection of Processed Small RNAs in Archaea

Author(s):
Christian Höner zu Siederdissen, Sarah Berkemer, Fabian Amman, Axel Wintsche, Sebastian Will, Sonja J. Prohaska, and Peter F. Stadler

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Abstract:
Enzymatic splicing in Archaeal tRNAs is guided by bulge-helix-bulge structural elements, while much less seems to be known about splicing in other small RNAs (sRNAs). We conduct a genome-wide analysis of several archaeal genomes to identify putative BHB elements and compare our findings with available RNA-seq data. We also provide an analysis of the viability of using pattern-based and stochastic structural scanning algorithms for in silico studies of the occurrence of BHB motifs. Furthermore, we comment on splicing motifs in other small RNAs, which mostly do not fit the pattern of bulge-helix-bulge motifs.

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