TBI-p-2015-1

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Titel:
forna (force-directed RNA): Simple and Effective Online RNA Secondary Structure Diagrams

Author(s):
Peter Kerpedjiev, Stefan Hammer and Ivo L. Hofacker

submitted to:
Bioinformatics

Abstract:
Motivation: The secondary structure of RNA is integral to the variety of functions it carries out in the cell and its depiction allows researchers to develop hypothesis about which nucleotides and base pairs are functionally relevant. Current approaches to visualizing secondary structure provide an adequate platform for the conversion of static text-based representations to two dimensional images, but are limited in their offer of interactivity as well as their ability to display larger structures, multiple structures and pseudoknotted structures. Results: In this paper we present forna, a web-based tool for displaying RNA secondary structure which allows users to easily convert sequences and secondary structures to clean, concise and customizable visualizations. It supports, among other features, the simultaneous visualization of multiple structures, the display of pseudoknotted structures, the interactive editing of the displayed structures, and the automatic generation of secondary structure diagrams from PDB files. It requires no software installation apart from a modern web browser. Availability: The web interface of forna is available at http: //nibiru.tbi.univie.ac.at/forna while the source code is available on github at www.github.com/pkerpedjiev/forna.

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