TBI-Preprint 05-04-001
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Titel:
Evolutionary patterns of non-coding RNAs
Author(s):
Athanasius F. Bompfünewerera,
Christoph Flamm,
Claudia Fried,
Guido Fritzsch,
Ivo L. Hofacker,
Jörg Lehmann,
Kristin Missal,
Axel Mosig,
Bettina Müller,
Sonja J. Prohaska,
Bärbel M.R. Stadler,
Peter F. Stadler,
Andrea Tanzer,
Stefan Washietl
and Christina Witwer
Appeared in:
Theor. Biosci., 123, 301-369 (2005)
Abstract:
A plethora of newfunctions of non-coding RNAs (ncRNAs) have been discovered
in past fewyears. In fact, RNA is emerging as the central player in
cellular regulation, taking on active roles in multiple regulatory layers
from transcription, RNA maturation, and RNA modification to translational
regulation. Nevertheless, very little is known about the evolution of this
"Modern RNA World" and its components. In this contribution, we attempt to
provide at least a cursory overviewof the diversity of ncRNAs and
functional RNA motifs in non-translated regions of regular messenger RNAs
(mRNAs) with an emphasis on evolutionary questions. This survey is
complemented by an in-depth analysis of examples from different classes of
RNAs focusing mostly on their evolution in the vertebrate lineage. We
present a survey of Y RNA genes in vertebrates and study the molecular
evolution of the U7 snRNA, the snoRNAs E1/U17, E2, and E3, the Y RNA
family, the let-7 microRNA (miRNA) family, and the mRNA-like evf-1 gene. We
furthermore discuss the statistical distribution of miRNAs in metazoans,
which suggests an explosive increase in the miRNA repertoire in
vertebrates. The analysis of the transcription of ncRNAs suggests that
small RNAs in general are genetically mobile in the sense that their
association with a hostgene (e.g. when transcribed from introns of a mRNA)
can change on evolutionary time scales. The let-7 family demonstrates, that
even the mode of transcription (as intron or as exon) can change among
paralogous ncRNA.
Keywords:
Evolution,
Non-coding RNA,
mRNA,
rRNA,
snRNA,
snoRNA,
miRNA,
Y-RNA,
Vault RNA,
gRNA,
RNA editing,
UTR
Alternative Numbers:
Return to 2005 working papers list.
Last modified: 2005-04-22 17:26:24 xtof