TBI-Preprint 05-08-001
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Titel:
The Expansion of the Metazoan MicroRNA Repertoire
Author(s):
Jana Hertel, Manuela Lindemeyer, Kristin Missal, Claudia Fried, Andrea
Tanzer, Christoph Flamm, Ivo L. Hofacker, Peter F. Stadler, and The
Students of Bioinformatics Computer Labs 2004 and 2005: Sten
Heinze, Alexander "muppet" Donath, Sven Findeß, Stephanie Keller,
Kevin Peter, Julian Jöris, Jokab Mühmel, Marco Dienelt (in
Leipzig), Martina Hödl, Bernhard Wurzinger, Camille Stephan-Otto
Attolini, Ulrich Omasits, Sebastian Krüttner, Regina Anzengruber,
Daniela Lenek, Gregor Neumayr, Reinhard Wohlfart (in Vienna).
Submitted to:
BMC Genomics
Abstract:
MicroRNAs have been identified as crucial regulators in both animals and
plants. Here we report on a comprehensive comparative study of all known
miRNA families in animals. We expand the MicroRNA Registry 6.0 by more than
1000 new homologs of miRNA precursors whose expression has been verified in
at least one species. Using this uniform data basis we analyze their
evolutionary history in terms of individual gene phylogenies and in terms
of preservation of genomic nearness across species. This allows us to
reliably identify microRNA clusters that are derived from a common
transcript. We identify three episodes of microRNA innovation that
correspond to major developmental innovations: A class of about 20 miRNAs
is common to protostomes and deuterostomes and might be related to the
advent of bilaterians. A second large wave of innovations maps to the
branch leading to the vertebrates. The third significant outburst of miRNA
innovation coincides with placental (eutherian) mammals. In addition, we
observe the expected expansion of the microRNA inventory due to genome
duplications in early vertebrates and in an ancestral teleost. The
non-local duplications in the vertebrate ancestor are predated by local
(tandem) duplications leading to the formation of about a dozend ancient
microRNA clusters.
Keywords:
Micro RNA,
Evolution,
Gene phylogenies,
Genome duplication
Alternative Numbers:
Bioinformatics Preprint 05-021
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Last modified: 2005-08-23 16:11:09 xtof