TBI-Preprint 06-05-001
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Titel:
RNAs Everywhere: Genome-Wide Annotation of Structured RNAs
Author(s):
Athanasius F. Bompfünewerer,
Rolf Backofen,
Stephan H. Bernhart,
Christoph Flamm,
Claudia Fried,
Guido Fritzsch,
Jörg Hackermüller,
Jana Hertel,
Ivo L. Hofacker,
Kristin Missal,
Axel Mosig,
Sonja J. Prohaska,
Dominic Rose,
Peter F. Stadler,
Andrea Tanzer,
Stefan Washietl,
Sebastian Will
Submitted to:
J. Exp. Zool. Mol. Part B: Devel. Evol. 2006
Abstract:
Starting with the discovery of microRNAs and the advent of genome-wide
transcriptomics, non-protein-coding transcripts have moved from a fringe
topic to a central field research in molecular biology. In this
contribution we review the state of the art of ``computational RNomics'',
i.e., the bioinformatics approaches to genome-wide RNA annotation. Instead
of rehashing results from recently published surveys in detail, we focus
here on the open problem in the field, namely (functional)
annotation of the plethora of putative RNAs. A series of exploratory
studies are used to provide non-trivial examples for the discussion of some
of the difficulties.
Keywords:
Noncoding RNA,
RNA Secondary Structure,
Genome Annotation
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Last modified: 2006-05-10 12:38:48 xtof