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Titel:
RNA Folding at Elementary Step Resolution
Author(s):
Christoph Flamm,
Walter Fontana,
Ivo L. Hofacker,
Peter Schuster
Appeared in:
RNA, 6, 325-338 (2000)
Abstract:
We study the stochastic folding kinetics of RNA sequences into
secondary structures with a new algorithm based on the formation,
dissociation, and the shifting of individual base pairs. We discuss
folding mechanisms and the correlation between the barrier structure
of the conformational landscape and the folding kinetics for a number
of examples based on artificial and natural sequences, including the
influence of base modification in tRNAs.
Keywords:
Conformational spaces,
foldability,
RNA folding kinetics,
RNA secondary structure.
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