TEACHING

Bachelor and Master Thesis

If you are interested in working with a group of highly motivated, and friendly people, don't hesitate to contact me.

Interesting research questions are:

Automatic transcription start site annotation:
In recent years high-throughput sequencing methods have been developed and are suitable to detect transcripts of a cell. One already successfully applied experimental approach (see for instance our publications Schmidtke et al. 2011 and Sharma et al. 2010 below) is differential RNA sequencing (dRNAseq). This approach has been developed to identify transcription start sites (TSS) of genes and operons. Given a dRNAseq data set we developed a computational method to automatically detect statistically significant TSS along the genome (for details see Schmidtke et al. 2011).

A prototype has been implemented in Perl and was applied to one data set. To be applicable for large-scale analysis it needs to be ported to C, C++ or an equivalent programming language. When ported, the approach has to be evaluated and compared with other methods. Hence the student has to re-implement the algorithm and subsequently deal with real world data sets.

SS 2013

Angebotene Veranstaltungen

Interessenten mögen sich bitte bei den Informationsveranstaltungen der Chemie in die Listen eintragen, sich direkt ueber den Moodle Link im Online Vorlesungsverzeichnis anmelden oder eine e-mail schicken mit den folgenden Informationen:

WS 2012/2013

Angebotene Veranstaltungen

270087 Vorlesung zu Struktur und Dynamik von Biopolymeren
Please check Moodle for further information and material.

270038 Übungen zu Struktur und Dynamik von Biopolymeren
Please check Moodle for further information and material.

SS 2011

Angebotene Veranstaltungen

270034 Übungen zu Algorithmen und Programmentwicklung für die Biologische Chemie
Further Information

270049 Praktikum zur Bioinformatik der Nukleinsäuren
Further Information

WS 2011/2012

Angebotene Veranstaltungen

270087 Vorlesung zu Struktur und Dynamik von Biopolymeren
Further Information

270038 Übungen zu Struktur und Dynamik von Biopolymeren
Further Information