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Titel:
Concurrent neutral evolution of mRNA secondary structures and encoded proteins

Author(s):
Jaromir Konecny, Michael Schöniger, Ivo L. Hofacker, Marc-Denis Weitze, G. Ludwig Hofacker

Appeared in:
J. Mol. Evol., 50: 238-242 (2000)

Abstract:
Messenger RNA sequences often have to preserve functional secondary structure elements in addition to coding for proteins. We present a statistical analysis of retroviral mRNA which supports the hypothesis that the natural genetic code is adapted to such complementary coding. These sequences are still able to efficiently explore the space of possible proteins by point mutations. This is borne out by the observation that in stem regions of retroviral mRNA foldings silent mutations on one strand are preferentially accompanied by conservative mutations on the other. Distances between amino acids based on physicochemical properties are used to quantify the conservation of protein function under the constraint of maintained RNA secondary structure. We find that preservation of RNA secondary structure by compensatory mutations is evolutionary compatible with the efficient search for new variants on the protein level.

Keywords:
Neutral evolution, mRNA secondary structure, Functional conservation

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