TBI-Preprint 08-01-002


Beyond Energy Minimization: Approaches to the kinetic Folding of RNA.

Christoph Flamm, Ivo L. Hofacker

Submitted to:
Chemistry Monthly (2008)

The term RNA folding is often used synonymously with the prediction of equilibrium structures. Yet many RNAs function thanks to their ability to undergo structural changes. In this contribution we present a systematic overview of existing approaches to the prediction of RNA folding kinetics, and in particular discuss the strengths and limitations of each method.

RNA folding kinetics, Monte Carlo simulation, Co-transcriptional folding, Folding pathway, Metastable structures.

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Last modified: 2008-02-26 18:41:14 xtof