Preprint 03-028

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Computational Chemistry with RNA Secondary Structures

Christoph Flamm, Ivo L. Hofacker, Peter F. Stadler

Submitted to:
K u I

The secondary structure for nucleic acids provides a level of description that is both abstract enough to allow for efficient algorithms and realistic enough to provide a good approximate to the thermodynamic and kinetics properties of RNA structure formation. The secondary structure model has furthermore been successful in explaining salient features of RNA evolution in nature and in the test tube. In this contribution we review the computational chemistry of RNA secondary structures using a simplified algorithmic approach for explanation.

Keywords: Nucleic Acids, RNA Folding, Structure Prediction, RNA Evolution.

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Last modified: 2004-02-11 13:08:49 ivo