Statistics of RNA Melting Kinectics

Manfred Tacker, Walter Fontana, Peter F. Stadler, and Peter Schuster

We present and study the behavior of a simple kinetic model for the melting of RNA secondary structures, given that those structures are known. The model is then used as a map that assigns structure dependent overall rate constants of melting (or refolding) to a sequence. This induces a ``landscape'' of reaction rates, or activation energies, over the space of sequences with fixed length. We study the distribution and the correlation structure of these activation energies.

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