TBI-p-2009-4
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Titel:
From consensus structure prediction to RNA gene finding
Author(s):
Stephan H Bernhart, Ivo L Hofacker
submitted to:
Abstract:
Reliable structure prediction is a prerequisite for most types of bioinformatical analysis of RNA. Since the accuracy
of structure prediction from single sequences is limited, one often resorts to computing the consensus structure for
a set of related RNA sequences. Since functionally important RNA structures are expected to evolve much more
slowly than the underlying sequences, the pattern of sequence (co-)variation can be exploited to dramatically improve
structure prediction. Since a conserved common structure is only expected when the RNA structure is under selective
pressure, consensus structure prediction also provides an ideal starting point for the de novo detection of structured
non-coding RNAs.
Here we review different strategies for the prediction of consensus secondary structures, and show how these
approaches can be used to predict non-coding RNA genes.
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