AREsite

AREsite (Gruber et al., 2011) is an online resource for the investigation of AU-rich elements (ARE) in vertebrate mRNA UTR sequences hosted at the Institute of Theoretical Chemistry, University of Vienna. AREs are one of the most prominent cis-acting regulatory elements found in 3’ vertebrate, untranslated regions of mRNAs. Various ARE-binding proteins that possess RNA stabilizing or destabilizing functions are recruited by sequence-specific motifs. This online resource allows detailed investigation of these functional elements by analysis of the phylogentic conservation and the structural context these motifs are embedded in. Moreover, AREsite provides information about experimentally validated targets from extensive literature search.

References

2011

  1. journal-article
    AREsite: a database for the comprehensive investigation of AU-rich elements
    A. R. Gruber, J. Fallmann, F. Kratochvill, and 2 more authors
    Nucleic Acids Research, 2011
    DOI