Info

Welcome to the 41^st TBI Winterseminar in Bled, exploring computational and theoretical biology and chemistry: (RNA-)bioinformatics, graph theory, cheminformatics, and metabolic network modeling. This year's event is organised by Max Faissner · Leonhard Sidl · Hua-Ting Yao.

Time

Sunday, 08 Feb 2026 - Friday, 13 Feb 2026

Registration Fee

300,- € (double room) / 425,- € (single room)

Participants

• Institute of Theoretical Chemistry (University of Vienna)
• Department of Bioinformatics (University of Leipzig)
• Chair of Bioinformatics (University of Freiburg)
• Center for non-coding RNA in Technology and Health (RTH) (University of Copenhagen)
• RNA Bioinformatics and High-Throughput Analysis Group (Friedrich Schiller University Jena)
• Algorithms and Models for Integrative Biology (École Polytechnique/CNRS)
• Department of Mathematics & Computer Science (University of Southern Denmark)
• and guests (by invitation only).

Location(s)

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Program

• Sun 0
• Mon 11
• Tue 15
• Wed 14
• Thu 9
• All 49

Arrival and Get Together at the Villa 8 Feb 20264pmVilla Plemlj

Comp Bio / Graph Theory 9 Feb 20263pmHotel Astoria

Session Chair: Marc Hellmuth
Slides	Speaker	Talk Title
	Christopher Stephens	A Bayesian Classifier Approach to Causal Inference in Complex Adaptive Systems
	Jose Antonio Ramirez Rafael	From Reviewer Requests to Rigorous Evaluation: Building Unbiased Benchmarks for Evolutionary Scenarios
	Stefan Müller	Self-fabrication (autocatalysis) in next-generation models of cellular growth
	Guillaume Scholz	Arboreal Ultrametrics
	Josef Leydold	Bubblespace on Hypergraphs
	Rebecca Holzschuh	Analysis of Complex Discrete Difference Data

Cheminformatics 9 Feb 20268pmHotel Astoria

Session Chair: Ivo Hofacker
Slides	Speaker	Talk Title
	Peter Stadler	Assembly on hypergraphs
	Richard Golnik	Enumerating autocatalytic subsystems in large chemical reaction networks
	Thanh-An Pham	SynArt: Attention in Reaction Prediction
	Lukas Böhm	🔮 Seismology of Rainbows: Measuring Spectrumquakes
	Aleksandra Olshanova	Molecular design using learnable graph grammars

Diet DNA 10 Feb 20262:30pmHotel Astoria

Session Chair: Hua-Ting Yao
Slides	Speaker	Talk Title
	Sebastian Will	News from RNA Pseudoknot Prediction
	Patrick-Pascal Koller	Disruptive Base-Pairs
	Leonhard Sidl	Designing novel xrRNA Structures using Infrared
	Katarina Gacevic	RNA Sequence Design with 2.5D Structural Constraints
	Cristian Velandia	Read-level Inference of tRNA Structures from Chemical Probing Data
	Thomas Spicher	The Impact of Modified Nucleotides on RNA Secondary Structure
	Paulina Sahul Holotova	🔮 Quantum Crochet: Entangling Scarves Across Light-Years
	Katrin Gutenbrunner	BlockBuster2D
	Lorenzo Favaro	RIsearch3 for Fast RNA-RNA Interaction Pedictions
	Mikkel Wolfhagen	GU in CRISPR off-targets: wobble or mismatch?

RNA / Comp Bio 10 Feb 20268pmHotel Astoria

Session Chair: Ronny Lorenz
Slides	Speaker	Talk Title
	Stefan Badelt	The fuzzyfold workspace: fast, modular, and extensible RNA folding kinetics
	Hannah Sophie Hartung	Cotranscriptional simulator to analyze ALU element interactions
	Yann Ponty	Exact partial algorithms for inverse folding
	Agata Kilar	Novel Structural Elements and How to Find Them? Nematoda edition.
	Daniel Wiegreffe	mdAnnotator - Visual Labeling of MD Simulations for Classification

Cheminfo II 12 Feb 20262:25pmHotel Astoria

Session Chair: Daniel Merkle
Slides	Speaker	Talk Title
	Joseph Smith	Using Graph Rewite Rules to Plan Novel Enzymatic Cascades
	Arina Shelashen	Encoding Chemical Intuition: The Challenge of Synthesizability Prediction
	Philipp Reiser	Bidirectional Mass Spectrometry Modeling Aided by Auxiliary Intermediate Steps From Graph Transformation Tools
	Klaus Weinbauer	On the Existence of Sufficient Explainers for Classification
	Akbar Davoodi	Exact and Agnostic Recovery in the Data Block Model
	Casper Asbjørn Eriksen	ChemRecon: Exploring Ontologies Within and Between Biochemical Databases
	Tieu-Long Phan	SynEdu
	Tuyet Minh Phan	SynDOKU: A Constraint Programming Framework for Chemical Reaction Network Assignment
	Nguyen Ngoc Vi Tran	Peptide pesticides off-target binding prediction
	Deza Amistas	Essential contexts in rule-based modeling

Phylo 11 Feb 20268pmHotel Astoria

Session Chair: Sebastian Will
Slides	Speaker	Talk Title
	Nadia Tahiri	Classification of Phylogenetic Networks: A Combinatorial Perspective
	Patricia Ebert	From Best Matches to Phylogenetic Networks
	Carlos Ugarte	Inferring ancestors and modeling change: A modular computational approach to disentangling language evolution
	Maximilian Faissner	From Structure to Screen: MD-Ready Enzyme-Substrate Pairs

Omics 12 Feb 20262:45pmHotel Astoria

Session Chair: Stephan Bernhart
Slides	Speaker	Talk Title
	Nino Bašić	Bipartite edge frustration of nut graphs
	Bruno Schmidt	TBA - most likely about transitive partition of directed graphs
	Anna Lindeberg	Networks from LCA constraints
	Karl Kaether	Automated Synteny Computation
	Dulce I. Valdivia	🔮 tRNAs
	Yitao Cai	sc-GRIP: A Graph Convolutional Approach to Infer Gene Interaction Polarity
	Ivan Andre Morillo Guerrero	Evolutionary origin of the LncRNA RMST in Tunicates
	Daniel Nimptsch	Full-length Isoform Splice-Aware Synthetic RNA-Seq Benchmark of Transcript Assemblers and Quantifiers

Origami 12 Feb 20269pmHotel Astoria

Session Chair: Christoph Flamm
Slides	Speaker	Talk Title
	Christoph Flamm	The Math of Origami

Registered Participants